Arthritis

Arthritis is an inflammation of the joints. It is caused by many disorders that affect the joints and their surrounding tissues. Arthritis affects people of all ages, but is more common in people over the age of 65.

Causes

Causes of arthritis depend on the specific type of arthritis and are detailed under the heading 'Types'.

Types

There are many types of arthritis. Some of the more common ones are:

Rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic and generally progressive autoimmune disorder causing inflammation of the membranes lining the joints. It typically affects the smaller joints of the hand and feet.

Osteoarthritis

Osteoarthritis (OA) is caused by the degeneration of cartilage, which loses its elasticity and becomes more easily damaged with age. It typically affects weight-bearing joints such as the hips and knees.

The progression of osteoarthritis. 

Juvenile arthritis

Juvenile arthritis is any type of arthritis occurring under the age of 16 years. As young people have not suffered from the same mechanical damage caused by ageing, most cases of arthritis in young people are likely due to autoimmune disorders, although the causes of many cases are unknown.

Infectious (septic) arthritis

Infectious arthritis is a joint infection due to bacteria, viruses or fungi. Usually the infection is established elsewhere in the body and reaches the joints by the bloodstream, or by getting directly into the joint through an open injury.

Polymyalgia rheumatica

Polymyalgia rheumatica is a type of arthritis that causes inflammation in the larger joints and their surrounding tissues, such as the hips and shoulder joints. It causes muscle pain and stiffness in these areas. It is a common form of arthritis and mainly affects the elderly, but it is treatable. It is not to be confused with fibromyalgia, a different condition in which muscle pain and stiffness can occur anywhere in the body, not just the joints. Fibromyalgia does not cause inflammation. Rather, it is likely the result of overactive pain signals.

Psoriatic arthritis

Psoriatic arthritis is an autoimmune disorder of the joints that can develop if you have psoriasis. While the exact cause is unknown, psoriatic arthritis is associated with HLA-B27, a protein on the surface of white blood cells that is linked to certain autoimmune disorders. If you have psoriatic arthritis, you should take note of what seems to trigger flare-ups, avoid those triggers and ensure you receive ongoing treatment as recommended by your doctor. In about 5% of cases, people develop a more severe form that results in bone deformities.

Gout

Gout is a type of arthritis caused by a build-up of uric acid (urate crystals) in the joints. Men are more likely to get gout, although the risk for women increases after menopause. Gout is one of the few causes of arthritis that can be effectively treated to prevent future damage.

Gout. 

Systemic lupus erythematous (SLE)

SLE, more commonly just referred to as lupus, is an autoimmune disorder. Its exact cause is unknown, but could be due to any or a combination of genetics, viruses, stress, or sunlight, among others. Flare-ups, which can vary in duration and severity, are periods when symptoms get worse. Most people with lupus can live a full life, if they stick to their treatment program. In some cases, however, complications can occur that can be life-threatening.

Bursitis

Bursitis is the inflammation of the bursa, which are small fluid-filled sacs between adjoining structures of joints, such as bones, muscles, and tendons. Technically bursitis is not a type of arthritis, because the bursa are outside the joints. It can be caused by injury or underlying conditions, such as rheumatoid arthritis.

Polymyositis

Polymyositis is a disorder of connective tissue that causes inflammation, the cause of which is unknown. It affects women more than men and tends to occur between the ages of 50-70 years, but can affect people of all ages.

Other types of arthritis include:

• Scleroderma;
• Reiter's syndrome, and;
• Tendinitis.

Signs and symptoms

Symptoms vary according to the cause of arthritis. Common symptoms include:

• Joint stiffness, swelling and pain;
• A skin rash around affected joints;
• Muscle weakness and wasting;
• Fever;
• Fatigue;
• Weight loss, and;
• Restlessness and anxiety.

Methods for diagnosis

Methods used to diagnose arthritis are:

Physical examination

Your doctor will likely look for signs of:

• Joint swelling, stiffness or tenderness;
• Redness or warmth around the joint due to inflammation;
• Restricted movement, and;
• Bumps or nodules.

Laboratory tests

Erythrocyte sedimentation rate (ESR)

ESR is a test used to indicate inflammation, but it does not diagnose a specific disorder. For this test a blood sample is taken and the rate at which red blood cells accumulate at the bottom of a test tube is measured. The higher the rate, the greater the degree of inflammation. Normal values will vary between laboratories according to different methods used. Your doctor will tell you what your results mean.

C-reactive protein (CRP)

Measuring CRP levels in the blood provides an indication of the degree of inflammation in the body. CRP is a general test that indicates that there is inflammation somewhere in the body, but does not localize the inflammation or identify its underlying cause. Your doctor may order this test to check if anti-inflammatory medicine is working, or during any flare-up periods of the inflammatory diseases.

Anti-cyclic citrullinated peptide (CCP) antibody

Anti-CCP antibodies are auto-antibodies, which means they are mistakenly directed against a person's healthy tissues instead of microorganisms. This test is used to confirm a diagnosis of rheumatoid arthritis.

Rheumatoid factor (RF)

RF is an auto-antibody directed against one of the body's antibodies, called immunoglobulin G (IgG). RF binds to IgG, forming immune complexes. When these complexes are deposited in the joints, they produce a reaction that causes inflammation. Up to 70% of people with rheumatoid arthritis have RF in their blood, but some people without rheumatoid arthritis can have it too.

Antinuclear antibody (ANA)

Normally the immune system produces antibodies to fight infection. ANAs attack your body's own cells. A positive result for ANAs does not necessarily mean you have an autoimmune disorder, because it can be caused by other conditions or certain medications. Some healthy people also have ANAs and this increases with age.

Human leucocyte antigen (HLA) B27 typing

HLAs are found on the surface of white blood cells. A particular type, HLA-B27, is associated with certain autoimmune disorders that may cause arthritis. In a healthy person, HLA-B27 will generally be absent, but its presence in your blood does not necessarily mean you have an autoimmune condition.

Other laboratory tests:

• Joint fluid tests;
• Creatinine and uric acid tests;
• Skin or muscle biopsy;
• Urine analysis, and;
• Serological tests for Lyme disease.

Other diagnostic tests:

• X-ray, computerized tomography (CT) scan, and magnetic resonance imaging (MRI);
• Ultrasound, and;
• Biopsy.

Types of treatment

Treatment options your doctor will consider include:

Medications

Pain-relief medications

These medications reduce pain and some are available without a prescription, such as acetaminophen and low-dose codeine. Some that require a prescription include oxycodone, propoxyphene and higher-dose codeine.

Non-steroidal anti-inflammatory drugs (NSAIDs)

NSAIDs are a group of medications that reduce inflammation, pain and fever. As such, they are used to ease these symptoms in a wide range of conditions. Examples are ibuprofen and naproxen.

Disease modifying anti-rheumatic drugs (DMARDs)

DMARDs are a range of drugs that act on the immune system in different ways to prevent inflammation. They include drugs such as methotrexate, sulfasalazine and hydroxychloroquine. Their effects are not immediate and can take weeks to months to be noticed. Unlike NSAIDs, early intervention with DMARDs can slow down disease progression.

Biological therapies

Biological therapies can work faster than DMARDs. They are drugs that act on the immune system and are sometimes used in conjunction with other medication if you have rheumatoid arthritis.

Corticosteroids

These are powerful anti-inflammatories that block the inflammatory pathway of the immune response. They can be taken orally or injected. Injection is usually only required in extreme cases of inflammation that only affect one or two joints.

Physiotherapy

Physiotherapy can help by improving mobility, flexibility and strength in arthritic joints.

Surgery

When non-surgical methods fail, an orthopedic surgeon may perform surgery to:

• Remove diseased or damaged tissue;
• Realign the joints;
• Release or repair tendons;
• Remove bone;
• Release trapped nerves;
• Fuse the ends of joint bones together to reduce joint motion and relieve pain, and;
• Replace a damaged joint with an artificial one.

Lifestyle

Exercise

Regular exercise can help improve flexibility, improve supporting-muscle strength and reduce fatigue.

Assistive devices

Assistive devices, such as walkers, canes and raised toilet seats, are available to help protect the joints and improve your ability to perform daily tasks.

Hot and cold packs

Applying icepacks or heating pads may help reduce pain. However, speak to your doctor first, as this can make some types of arthritis worse.

Other therapies

Unproven therapies for arthritis include oral glucosamine and chondroitin, and acupuncture.

Potential complications

Medications

Non-steroidal anti-inflammatory drugs (NSAIDs)

Side effects associated with long-term use of NSAIDs can be gastritis and ulcers in the digestive system. NSAIDs can also interact with other drugs. If you are taking NSAIDs for arthritis, your doctor or pharmacist will tell you what drugs you should not mix with them.

DMARDS

DMARDs can have a wide range of side effects depending on the agent used. Methotrexate can weaken the immune system, resulting in increased susceptibility to infection. It can also cause damage to the lungs and liver. Side effects and potential complications will be closely monitored by your treating doctor.

Biological therapies

Biological therapies can result in the formation of anti-drug antibodies (ADAs), which can reduce the effectiveness of a treatment. Further research is needed to identify the optimal dosage required to reduce the problem of ADA formation. Biological therapies can also weaken the immune system, making it harder for the body to fight infections.

Corticosteroids

Side effects of long-term oral or intravenous corticosteroids, include osteoporosis, a weakened immune system, weight gain, glaucoma, muscle weakness and elevated blood pressure.

Prognosis

The outlook for arthritis varies, according to the underlying cause and response to treatment. Most forms of arthritis are chronic, with only a few able to be cured with treatment. Early diagnosis generally results in better treatment outcomes.

Prevention

Ways you can help prevent the development of arthritis include:

• Regular exercise and maintaining a healthy weight;
• Avoiding high-impact sports if you suffer from arthritis;
• Quitting smoking, because it can impair the healing of tissues, and;
• Taking breaks from work and getting enough sleep.